ForC lacks canonical formin activity but bundles actin filaments and is required for multicellular development of Dictyostelium cells.

doi:10.1016/j.ejcb.2013.07.001

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Article

ForC lacks canonical formin activity but bundles actin filaments and is required for multicellular development of Dictyostelium cells.

European journal of cell biology - 1 Jan 2000

Junemann Alexander, Winterhoff Moritz, Nordholz Benjamin, Rottner Klemens, Eichinger Ludwig, Gräf Ralph, Faix Jan

Abstract excerpt

Diaphanous-related formins (DRFs) drive the nucleation and elongation of linear actin filaments downstream of Rho GTPase signalling pathways. Dictyostelium formin C (ForC) resembles a DRF, except that it lacks a genuine formin homology domain 1 (FH1), raising the questions whether or not ForC can nucleate and elongate actin filaments. We found that a recombinant ForC-FH2 fragment does not nucleate actin...

Topics

Actin Cytoskeleton
Actins
Cell Movement
Cyclic AMP
Dictyostelium
Gene Expression Regulation, Developmental
Microfilament Proteins
Mutation
Protozoan Proteins
Spores, Protozoan

Source

Open in PubMed

Identifiers

PMID: 23906540
DOI: 10.1016/j.ejcb.2013.07.001

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