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tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis.

Genes & development - 15 Aug 2008

Tang Linnan, Franca-Koh Jonathan, Xiong Yuan, Chen Mei-Yu, Long Yu, Bickford Ross M, Knecht David A, Iglesias Pablo A, Devreotes Peter N

Abstract excerpt

In a forward genetic screen for chemotaxis mutants in Dictyostelium discoideum, we identified a loss-of-function mutation, designated tsunami, encoding a homolog of the Fused kinase. Cells lacking tsuA function could not effectively perform chemotaxis and were unable to become polarized or correctly orient pseudopods in chemotactic gradients. While tsuA(-) cells were able to couple receptor occupancy to...

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Identifiers

PMID: 18708585
DOI: 10.1101/gad.1694508
PMCID: PMC2518819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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