Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes.

The Journal of biological chemistry - 24 Dec 2010

Chen Wei, Dong Qinghua, Shin Ki-Hyuk, Kim Reuben H, Oh Ju-Eun, Park No-Hee, Kang Mo K

Abstract excerpt

We recently identified Grainyhead-like 2 (GRHL2) as a novel transcription factor that binds to and regulates the activity of the human telomerase reverse transcriptase (hTERT) gene promoter. In this study, we investigated the biological functions of GRHL2 and the molecular mechanism underlying hTERT gene regulation by GRHL2. Retroviral transduction of GRHL2 in normal human keratinocytes (NHK) led to a significant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Enzymologic

Share to Gene Knockdown Techniques

Share to Keratinocytes

Share to Response Elements

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 20938050
DOI: 10.1074/jbc.M110.103812
PMCID: PMC3003386

Genes

GRHL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes.PMID 20938050Read ↗

Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanismSemantic proximity Read ↗

Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epitheliumSemantic proximity Read ↗

Coordinated expression and genetic polymorphisms in Grainyhead-like genes in human non-melanoma skin cancers.Semantic proximity Read ↗

Grhl2 determines the epithelial phenotype of breast cancers and promotes tumor progression.Semantic proximity Read ↗

Genome-wide identification of binding sites of GRHL2 in luminal-like and basal A subtypes of breast cancerSemantic proximity Read ↗

Long noncoding RNA MEG3 blocks telomerase activity in human liver cancer stem cells epigeneticallySemantic proximity Read ↗

The p63 Gene Is Regulated by Grainyhead-like 2 (GRHL2) through Reciprocal Feedback and Determines the Epithelial Phenotype in Human Keratinocytes.Semantic proximity Read ↗

Hairless regulates p53 target genes to exert tumor suppressive functions in glioblastoma.Semantic proximity Read ↗

Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interactionSemantic proximity Read ↗

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.Semantic proximity Read ↗

2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter.Semantic proximity Read ↗

The long non-coding RNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.