Article
2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter.
Cell reports - 30 May 2017
Yang Zhentao, Jiang Bin, Wang Yan, Ni Hengxiao, Zhang Jia, Xia Jinmei, Shi Minggang, Hung Li-Man, Ruan Jingsong, Mak Tak Wah, Li Qinxi, Han Jiahuai
Abstract excerpt
2-hydroxyglutarate-(2-HG)-mediated inhibition of TET2 activity influences DNA hypermethylation in cells harboring mutations of isocitrate dehydrogenases 1 and 2 (IDH1/2). Here, we show that 2-HG also regulates DNA methylation mediated by DNA methyltransferase 1 (DNMT1). DNMT1-dependent hypermethylation of the RIP3 promoter occurred in both IDH1 R132Q knockin mutant mouse embryonic fibroblast (MEFs) and...
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