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Article

The p63 Gene Is Regulated by Grainyhead-like 2 (GRHL2) through Reciprocal Feedback and Determines the Epithelial Phenotype in Human Keratinocytes.

The Journal of biological chemistry - 7 Aug 2015

Mehrazarin Shebli, Chen Wei, Oh Ju-Eun, Liu Zi X, Kang Kyung L, Yi Jin K, Kim Reuben H, Shin Ki-Hyuk, Park No-Hee, Kang Mo K

Abstract excerpt

In this study, we investigated the effects of p63 modulation in epithelial plasticity in human keratinocytes. The p63 isoforms ΔNp63α, ΔNp63β, and ΔNp63γ were ectopically expressed in normal human epidermal keratinocytes (NHEKs). The epithelial or mesenchymal state was determined by morphological changes and altered expression of various markers, e.g. fibronectin, E-Cadherin, and keratin 14. Overexpression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26085095
DOI: 10.1074/jbc.M115.659144
PMCID: PMC4528158

Genes

GRHL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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