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Article

Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.

Nucleic acids research - 28 Feb 2018

Ming Qianqian, Roske Yvette, Schuetz Anja, Walentin Katharina, Ibraimi Ibraim, Schmidt-Ott Kai M, Heinemann Udo

Abstract excerpt

Grainyhead (Grh)/CP2 transcription factors are highly conserved in multicellular organisms as key regulators of epithelial differentiation, organ development and skin barrier formation. In addition, they have been implicated as being tumor suppressors in a variety of human cancers. Despite their physiological importance, little is known about their structure and DNA binding mode. Here, we report the first...

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Identifiers

PMID: 29309642
DOI: 10.1093/nar/gkx1299
PMCID: PMC5829564

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