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Long noncoding RNA MEG3 blocks telomerase activity in human liver cancer stem cells epigenetically

30 Nov 2020

Abstract excerpt

BACKGROUND: MEG3 downregulated the expression in several tumors and inhibits human tumorigenesis. But so far, the mechanism of MEG3 in tumorigenesis is still unclear. METHODS: In gene infection, cellular and molecular technologies and tumorigenesis test in vitro and in vivo were performed, respectively. RESULTS: Our results indicate that MEG3 enhances the P53 expression by triggering the loading of P300 and RNA...

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PMID: 33256840
DOI: 10.1186/s13287-020-02036-4

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