Article
Adaptation to diverse nitrogen-limited environments by deletion or extrachromosomal element formation of the GAP1 locus.
Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 2010
Gresham David, Usaite Renata, Germann Susanne Manuela, Lisby Michael, Botstein David, Regenberg Birgitte
Abstract excerpt
To study adaptive evolution in defined environments, we performed evolution experiments with Saccharomyces cerevisiae (yeast) in nitrogen-limited chemostat cultures. We used DNA microarrays to identify copy-number variation associated with adaptation and observed frequent amplifications and deletions at the GAP1 locus. GAP1 encodes the general amino acid permease, which transports amino acids across the plasma...
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