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Article

Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 2002

Dunham Maitreya J, Badrane Hassan, Ferea Tracy, Adams Julian, Brown Patrick O, Rosenzweig Frank, Botstein David

Abstract excerpt

Genome rearrangements, especially amplifications and deletions, have regularly been observed as responses to sustained application of the same strong selective pressure in microbial populations growing in continuous culture. We studied eight strains of budding yeast (Saccharomyces cerevisiae) isolated after 100-500 generations of growth in glucose-limited chemostats. Changes in DNA copy number were assessed at...

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Identifiers

PMID: 12446845
DOI: 10.1073/pnas.242624799
PMCID: PMC138579

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