Paths to adaptation under fluctuating nitrogen starvation: The spectrum of adaptive mutations in Saccharomyces cerevisiae is shaped by retrotransposons and microhomology-mediated recombination.

Abstract excerpt

There are many mechanisms that give rise to genomic change: while point mutations are often emphasized in genomic analyses, evolution acts upon many other types of genetic changes that can result in less subtle perturbations. Changes in chromosome structure, DNA copy number, and novel transposon insertions all create large genomic changes, which can have correspondingly large impacts on phenotypes and fitness. In...

Topics

• Saccharomyces cerevisiae
• Retroelements
• Nitrogen
• Adaptation, Physiological
• Mutation
• Recombination, Genetic
• Glucose
• Selection, Genetic