Article

Copy number variants alter local and global mutational tolerance

2022-12-31

Abstract excerpt

Copy number variants (CNVs), duplications and deletions of genomic content, contribute to evolutionary adaptation, but can also confer deleterious effects, and cause disease. Whereas the effects of amplifying individual genes or whole chromosomes (i.e., aneuploidy) have been studied extensively, much less is known about the genetic and functional effects of CNVs of differing sizes and structures. Here, we investig...

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Literature Corpus work: fa354f98-7ce9-50f2-ad05-32b9377b0cb8
DOI: 10.1101/2022.12.30.521611

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