Article
Adaptive mutation sequences reproduced by mismatch repair deficiency.
Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 1995
Longerich S, Galloway A M, Harris R S, Wong C, Rosenberg S M
Abstract excerpt
Adaptive reversions of a lac frameshift mutation in Escherichia coli are -1 deletions in small mononucleotide repeats, whereas growth-dependent reversions are heterogeneous. The adaptive mutations resemble instability of simple repeats, which, in hereditary colon cancer, in yeast, and in E. coli...
Topics
- Bacterial Proteins
- Base Composition
- Base Sequence
- Colonic Neoplasms
- DNA Repair
- Escherichia coli
- Escherichia coli Proteins
- Genes, Bacterial
- Humans
- Lac Repressors
- Models, Genetic
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Repetitive Sequences, Nucleic Acid
- Repressor Proteins
- Saccharomyces cerevisiae
- Sequence Deletion