Article
The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast.
PLoS genetics - 1 Dec 2008
Gresham David, Desai Michael M, Tucker Cheryl M, Jenq Harry T, Pai Dave A, Ward Alexandra, DeSevo Christopher G, Botstein David, Dunham Maitreya J
Abstract excerpt
The experimental evolution of laboratory populations of microbes provides an opportunity to observe the evolutionary dynamics of adaptation in real time. Until very recently, however, such studies have been limited by our inability to systematically find mutations in evolved organisms. We overcom...
Topics
- Adaptation, Physiological
- Evolution, Molecular
- Gene Deletion
- Gene Duplication
- Gene Expression Profiling
- Genotype
- Glucose
- Molecular Sequence Data
- Mutation
- Oligonucleotide Array Sequence Analysis
- Phenotype
- Phosphates
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins