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Article

The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Samaranch Lluís, Cervantes Sebastián, Barabash Ana, Alonso Alvaro, Cabranes José Antonio, Lamet Isabel, Ancín Inés, Lorenzo Elena, Martínez-Lage Pablo, Marcos Alberto, Clarimón Jordi, Alcolea Daniel, Lleó Alberto, Blesa Rafael, Gómez-Isla Teresa, Pastor Pau

Abstract excerpt

Microtubule-associated protein tau (MAPT) and apolipoprotein E (APOE) are involved in the pathogenic mechanisms of Alzheimer's disease (AD). We prospectively followed three longitudinal independent samples (total n=319) with amnestic mild cognitive impairment (MCI) and analyzed whether MAPT H1/H2 haplotypes and APOE ε4 polymorphisms accelerated the rate of progression from MCI to dementia. At the end of the...

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Source

Identifiers

PMID: 20930301
DOI: 10.3233/JAD-2010-101011

Genes

APOE
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia.PMID 20930301Read ↗

Accelerated progression from mild cognitive impairment to dementia among APOE ε4ε4 carriers.Semantic proximity Read ↗

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Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis.Semantic proximity Read ↗

MAPT H1 Haplotype is Associated with Late-Onset Alzheimer's Disease Risk in APOEɛ4 Noncarriers: Results from the Dementia Genetics Spanish Consortium.Semantic proximity Read ↗

An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.Semantic proximity Read ↗

Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer's diseaseSemantic proximity Read ↗

Genetic risk of neurodegenerative diseases is associated with mild cognitive impairment and conversion to dementia.Semantic proximity Read ↗

Apolipoprotein E genotypes and plasma levels in mild cognitive impairment conversion to Alzheimer's disease: A follow-up study.Semantic proximity Read ↗

The MAPT H1 Haplotype Is a Risk Factor for Alzheimer’s Disease in APOE ε4 Non-carriersSemantic proximity Read ↗

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