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Article

The H1 haplotype of the tau gene (MAPT) is associated with mild cognitive impairment.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Di Maria Emilio, Cammarata Sergio, Parodi Maria Isola, Borghi Roberta, Benussi Luisa, Galli Marialaura, Galimberti Daniela, Ghidoni Roberta, Gonella Davide, Novello Cristina, Pollero Valeria, Perroni Lucia, Odetti Patrizio, Scarpini Elio, Binetti Giuliano, Tabaton Massimo

Abstract excerpt

Mild cognitive impairment is often considered a transitional condition prodromal to Alzheimer's disease. The dissection of genetic risk factors predisposing to mild cognitive impairment is paramount to assess the individual predisposition and reliably evaluate the effectiveness of early therapeutic interventions. We designed a cross-sectional analysis to test whether the occurrence of mild cognitive impairment is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 20157246
DOI: 10.3233/JAD-2010-1285

Genes

APOE
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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The H1 haplotype of the tau gene (MAPT) is associated with mild cognitive impairment.PMID 20157246Read ↗

The effect of MAPT H1 and APOE ε4 on transition from mild cognitive impairment to dementia.Semantic proximity Read ↗

The MAPT H1 Haplotype Is a Risk Factor for Alzheimer’s Disease in APOE ε4 Non-carriersSemantic proximity Read ↗

MAPT H1 Haplotype is Associated with Late-Onset Alzheimer's Disease Risk in APOEɛ4 Noncarriers: Results from the Dementia Genetics Spanish Consortium.Semantic proximity Read ↗

An association study of common variation at the MAPT locus with late-onset Alzheimer's disease.Semantic proximity Read ↗

An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.Semantic proximity Read ↗

Tau haplotypes and ApoE4 do not act in synergy on Alzheimer's disease.Semantic proximity Read ↗

MAPT Haplotype Variation and Alzheimer's Disease Risk: A Narrative Review with Focus on the Jordanian Population.Semantic proximity Read ↗

The MAPT H1 haplotype is associated with tangle-predominant dementia.Semantic proximity Read ↗

Interaction with the MAPT H1H1 Genotype Increases Dementia Risk in APOE ε4 Carriers in a Population of Southern India.Semantic proximity Read ↗

Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia.Semantic proximity Read ↗

Selective brain gray matter atrophy associated with APOE ε4 and MAPT H1 in subjects with mild cognitive impairment.Semantic proximity Read ↗

The Risk of Incident Mild Cognitive Impairment and Progression to Dementia Considering Mild Cognitive Impairment SubtypesSemantic proximity Read ↗

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