Article
Two histone marks establish the inner centromere and chromosome bi-orientation.
Science (New York, N.Y.) - 8 Oct 2010
Yamagishi Yuya, Honda Takashi, Tanno Yuji, Watanabe Yoshinori
Abstract excerpt
For proper partitioning of chromosomes in mitosis, the chromosomal passenger complex (CPC) including Aurora B and survivin must be localized at the center of paired kinetochores, at the site called the inner centromere. It is largely unknown what defines the inner centromere and how the CPC is targeted to this site. Here, we show that the phosphorylation of histone H3-threonine 3 (H3-pT3) mediated by Haspin...
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