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Article

Complex formation of Plk1 and INCENP required for metaphase-anaphase transition.

Nature cell biology - 1 Feb 2006

Goto Hidemasa, Kiyono Tohru, Tomono Yasuko, Kawajiri Aie, Urano Takeshi, Furukawa Koichi, Nigg Erich A, Inagaki Masaki

Abstract excerpt

Mitotic chromosomal dynamics is regulated by the coordinated activities of many mitotic kinases, such as cyclin-dependent kinase 1 (Cdk1), Aurora-B or Polo-like kinase 1 (Plk1), but the mechanisms of their coordination remain unknown. Here, we report that Cdk1 phosphorylates Thr 59 and Thr 388 on inner centromere protein (INCENP), which regulates the localization and kinase activity of Aurora-B from prophase to...

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Source

Identifiers

PMID: 16378098
DOI: 10.1038/ncb1350

Genes

INCENP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Complex formation of Plk1 and INCENP required for metaphase-anaphase transition.PMID 16378098Read ↗

A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis.Semantic proximity Read ↗

Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1.Semantic proximity Read ↗

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.Semantic proximity Read ↗

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.Semantic proximity Read ↗

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