Article
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity.
Proceedings of the National Academy of Sciences of the United States of America - 19 Oct 2010
Beekman Marian, Nederstigt Christa, Suchiman H Eka D, Kremer Dennis, van der Breggen Ruud, Lakenberg Nico, Alemayehu Wendimagegn Ghidey, de Craen Anton J M, Westendorp Rudi G J, Boomsma Dorret I, de Geus Eco J C, Houwing-Duistermaat Jeanine J, Heijmans Bastiaan T, Slagboom P Eline
Abstract excerpt
A set of currently known alleles increasing the risk for coronary artery disease, cancer, and type 2 diabetes as identified by genome-wide association studies was tested for compatibility with human longevity. Here, we show that nonagenarian siblings from long-lived families and singletons older than 85 y of age from the general population carry the same number of disease risk alleles as young controls. Longevity...
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