Discovering joint associations between disease and gene pairs with a novel similarity test.

Abstract excerpt

BACKGROUND: Genes in a functional pathway can have complex interactions. A gene might activate or suppress another gene, so it is of interest to test joint associations of gene pairs. To simultaneously detect the joint association between disease and two genes (or two chromosomal regions), we propose a new test with the use of genomic similarities. Our test is designed to detect epistasis in the absence of main...

Topics

• Disease
• Epistasis, Genetic
• Haplotypes
• Models, Genetic
• Polymorphism, Single Nucleotide