Article
Similarity-based multimarker association tests for continuous traits.
Annals of human genetics - 1 May 2012
Lin Wan-Yu, Tiwari Hemant K, Gao Guimin, Zhang Kui, Arcaroli John J, Abraham Edward, Liu Nianjun
Abstract excerpt
Testing multiple markers simultaneously not only can capture the linkage disequilibrium patterns but also can decrease the number of tests and thus alleviate the multiple-testing penalty. If a gene is associated with a phenotype, subjects with similar genotypes in this gene should also have similar phenotypes. Based on this concept, we have developed a general framework that is applicable to continuous traits....
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