Reexamining Dis/Similarity-Based Tests for Rare-Variant Association with Case-Control Samples.

Abstract excerpt

A properly designed distance-based measure can capture informative genetic differences among individuals with different phenotypes and can be used to detect variants responsible for the phenotypes. To detect associated variants, various tests have been designed to contrast genetic dissimilarity or similarity scores of certain subject groups in different ways, among which the most widely used strategy is to...

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