Article
Constructing a gene semantic similarity network for the inference of disease genes.
BMC systems biology - 1 Jan 2011
Jiang Rui, Gan Mingxin, He Peng
Abstract excerpt
MOTIVATION: The inference of genes that are truly associated with inherited human diseases from a set of candidates resulting from genetic linkage studies has been one of the most challenging tasks in human genetics. Although several computational approaches have been proposed to prioritize candidate genes relying on protein-protein interaction (PPI) networks, these methods can usually cover less than half of...
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