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Article

Haplotype-based methods for detecting uncommon causal variants with common SNPs.

Genetic epidemiology - 1 Sept 2012

Lin Wan-Yu, Yi Nengjun, Zhi Degui, Zhang Kui, Gao Guimin, Tiwari Hemant K, Liu Nianjun

Abstract excerpt

Detecting uncommon causal variants (minor allele frequency [MAF] < 5%) is difficult with commercial single-nucleotide polymorphism (SNP) arrays that are designed to capture common variants (MAF > 5%). Haplotypes can provide insights into underlying linkage disequilibrium (LD) structure and can tag uncommon variants that are not well tagged by common variants. In this work, we propose a wei-SIMc-matching test that...

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Identifiers

PMID: 22706849
DOI: 10.1002/gepi.21650
PMCID: PMC3513398

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MAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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