Article
Discovering pair-wise genetic interactions: an information theory-based approach.
PloS one - 1 Jan 2014
Ignac Tomasz M, Skupin Alexander, Sakhanenko Nikita A, Galas David J
Abstract excerpt
Phenotypic variation, including that which underlies health and disease in humans, results in part from multiple interactions among both genetic variation and environmental factors. While diseases or phenotypes caused by single gene variants can be identified by established association methods and family-based approaches, complex phenotypic traits resulting from multi-gene interactions remain very difficult to...
Topics
- Animals
- Body Weight
- Epistasis, Genetic
- Female
- Genetic Markers
- Humans
- Information Theory
- Male
- Mice
- Models, Genetic
- Phenotype
- Polymorphism, Single Nucleotide