Article
Brain molecular aging, promotion of neurological disease and modulation by sirtuin 5 longevity gene polymorphism.
Neurobiology of disease - 1 Feb 2011
Glorioso Christin, Oh Sunghee, Douillard Gaelle Guilloux, Sibille Etienne
Abstract excerpt
Mechanisms determining characteristic age-of-onset for neurological diseases are largely unknown. Normal brain aging associates with robust and progressive transcriptome changes ("molecular aging"), but the intersection with disease pathways is mostly uncharacterized. Here, using cross-cohort microarray analysis of four human brain areas, we show that neurological disease pathways largely overlap with molecular...
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