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Article

Older molecular brain age in severe mental illness.

Molecular psychiatry - 1 Jul 2021

Lin Chien-Wei, Chang Lun-Ching, Ma Tianzhou, Oh Hyunjung, French Beverly, Puralewski Rachel, Mathews Fasil, Fang Yusi, Lewis David A, Kennedy James L, Mueller Daniel, Marshe Victoria S, Jaffe Andrew, Chen Qiang, Ursini Gianluca, Weinberger Daniel, Newman Anne B, Lenze Eric J, Nikolova Yuliya S, Tseng George C, Sibille Etienne

Abstract excerpt

Psychiatric disorders are associated with accelerated aging and enhanced risk for neurodegenerative disorders. Brain aging is associated with molecular, cellular, and structural changes that are robust on the group level, yet show substantial inter-individual variability. Here we assessed deviations in gene expression from normal age-dependent trajectories, and tested their validity as predictors of risk for...

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Brain
Depressive Disorder, Major
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mental Disorders

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Identifiers

PMID: 32632206
DOI: 10.1038/s41380-020-0834-1
PMCID: PMC7785531

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