Article
Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor.
Nature medicine - 1 Dec 2008
Varela-Rohena Angel, Molloy Peter E, Dunn Steven M, Li Yi, Suhoski Megan M, Carroll Richard G, Milicic Anita, Mahon Tara, Sutton Deborah H, Laugel Bruno, Moysey Ruth, Cameron Brian J, Vuidepot Annelise, Purbhoo Marco A, Cole David K, Phillips Rodney E, June Carl H, Jakobsen Bent K, Sewell Andrew K, Riley James L
Abstract excerpt
HIV's considerable capacity to vary its HLA-I-restricted peptide antigens allows it to escape from host cytotoxic T lymphocytes (CTLs). Nevertheless, therapeutics able to target HLA-I-associated antigens, with specificity for the spectrum of preferred CTL escape mutants, could prove effective. Here we use phage display to isolate and enhance a T-cell antigen receptor (TCR) originating from a CTL line derived from...
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