Article
The FOXO3A rs2802292 G-allele associates with improved peripheral and hepatic insulin sensitivity and increased skeletal muscle-FOXO3A mRNA expression in twins.
The Journal of clinical endocrinology and metabolism - 1 Jan 2011
Banasik Karina, Ribel-Madsen Rasmus, Gjesing Anette P, Wegner Lise, Andersson Asa, Poulsen Pernille, Borglykke Anders, Witte Daniel R, Pedersen Oluf, Hansen Torben, Vaag Allan
Abstract excerpt
OBJECTIVE: The minor G-allele of FOXO3A rs2802292 has been associated with longevity. We aimed to investigate whether a phenotype related to healthy metabolic aging could be identified in individuals carrying the longevity-associated FOXO3A rs2802292 G-allele. RESEARCH DESIGN AND METHODS: rs2802292 was genotyped in a phenotypically well-characterized population of young and elderly twins (n = 190) and in the...
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