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Article

Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels.

GeroScience - 1 Apr 2022

Frankum Ryan, Jameson Tom S O, Knight Bridget A, Stephens Francis B, Wall Benjamin T, Donlon Timothy A, Torigoe Trevor, Willcox Bradley J, Willcox D Craig, Allsopp Richard C, Harries Lorna W

Abstract excerpt

The rs2802292, rs2764264 and rs13217795 variants of FOXO3 have been associated with extreme longevity in multiple human populations, but the mechanisms underpinning this remain unclear. We aimed to characterise potential effects of longevity-associated variation on the expression and mRNA processing of the FOXO3 gene. We performed a comprehensive assessment of FOXO3 isoform usage across a wide variety of human...

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Identifiers

PMID: 34436732
DOI: 10.1007/s11357-021-00431-0
PMCID: PMC9135902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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