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Article

Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes.

The Journal of clinical endocrinology and metabolism - 1 Apr 2009

Müssig Karsten, Staiger Harald, Machicao Fausto, Stancáková Alena, Kuusisto Johanna, Laakso Markku, Thamer Claus, Machann Jürgen, Schick Fritz, Claussen Claus D, Stefan Norbert, Fritsche Andreas, Häring Hans-Ulrich

Abstract excerpt

CONTEXT: The transcription factor forkhead box protein (FOX) O1A plays a crucial role in regulation of beta-cell function and metabolic effects of insulin in the liver. OBJECTIVE: The objective of the study was to investigate whether common genetic variation within the FOXO1 gene encoding FOXO1A contributes to prediabetic phenotypes, such as insulin resistance or beta-cell dysfunction, and to risk of type 2...

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Identifiers

PMID: 19141580
DOI: 10.1210/jc.2008-1048

Genes

FOXO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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