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Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.

Cell metabolism - 1 Sept 2008

Seiler Alexander, Schneider Manuela, Förster Heidi, Roth Stephan, Wirth Eva K, Culmsee Carsten, Plesnila Nikolaus, Kremmer Elisabeth, Rådmark Olof, Wurst Wolfgang, Bornkamm Georg W, Schweizer Ulrich, Conrad Marcus

Abstract excerpt

Oxidative stress in conjunction with glutathione depletion has been linked with various acute and chronic degenerative disorders, yet the molecular mechanisms have remained unclear. In contrast to the belief that oxygen radicals are detrimental to cells and tissues by unspecific oxidation of essential biomolecules, we now demonstrate that oxidative stress is sensed and transduced by glutathione peroxidase 4...

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PMID: 18762024
DOI: 10.1016/j.cmet.2008.07.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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