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Article

NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.

Scientific reports - 7 Dec 2016

Nlandu-Khodo Stellor, Dissard Romain, Hasler Udo, Schäfer Matthias, Pircher Haymo, Jansen-Durr Pidder, Krause Karl Heinz, Martin Pierre-Yves, de Seigneux Sophie

Abstract excerpt

NADPH oxidase 4 (NOX4) is highly expressed in kidney proximal tubular cells. NOX4 constitutively produces hydrogen peroxide, which may regulate important pro-survival pathways. Renal ischemia reperfusion injury (IRI) is a classical model mimicking human ischemic acute tubular necrosis. We hypothesized that NOX4 plays a protective role in kidney IRI. In wild type (WT) animals subjected to IRI, NOX4 protein...

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Source

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Identifiers

PMID: 27924932
DOI: 10.1038/srep38598
PMCID: PMC5141508

Genes

NOX4
KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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