Article
[Analysis of clusterin gene (CLU/APOJ) polymorphism in Alzheimer's disease patients and in normal cohorts from Russian populations].
Molekuliarnaia biologiia - 1 Jan 2000
Golenkina S A, Gol'tsov A Iu, Kuznetsova I L, Grigorenko A P, Andreeva T V, Reshetov D A, Kunizheva S S, Shagam L I, Morozova I Iu, Goldenkova-Pavlova I V, Shimshilashvili Kh, Viacheslavova A O, Faskhutdinova G, Gareeva A É, Zaĭnullina A G, Khusnutdinova É K, Puzyrev V P, Stepanov V A, Kolotvin A V, Samokhodskaia L M, Selezneva N D, Gavrilova S I, Rogaev E I
Abstract excerpt
Three genes mutations in which cause familial forms of Alzheimer's disease are known to date:PSEN1, PSEN2 and APP; and APOE gene polymorphism is a strong risk factor for Alzheimer's disease. We have evaluated allele and genotype frequency distribution of rs11136000 polymorphism in clusterin (CLU) gene (or apolipoprotein J, APOJ) in populations of three Russian regions and i nAlzheimhner's diseasepatients....
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