Analyzing 74,248 Samples Confirms the Association Between CLU rs11136000 Polymorphism and Alzheimer's Disease in Caucasian But Not Chinese population.

doi:10.1038/s41598-018-29450-2

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Analyzing 74,248 Samples Confirms the Association Between CLU rs11136000 Polymorphism and Alzheimer's Disease in Caucasian But Not Chinese population.

Scientific reports - 23 Jul 2018

Han Zhijie, Qu Jiaojiao, Zhao Jiehong, Zou Xiao

Abstract excerpt

Clusterin (CLU) is considered one of the most important roles for pathogenesis of Alzheimer's Disease (AD). The early genome-wide association studies (GWAS) identified the CLU rs11136000 polymorphism is significantly associated with AD in Caucasian. However, the subsequent studies are unable to replicate these findings in different populations. Although two independent meta-analyses show evidence to support...

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PMID: 30038359
DOI: 10.1038/s41598-018-29450-2
PMCID: PMC6056482

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