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Article

Gene expression profiling of white adipose tissue reveals paternal transmission of proneness to obesity.

Scientific reports - 12 Feb 2016

Morita Sumiyo, Nakabayashi Kazuhiko, Kawai Tomoko, Hayashi Keiko, Horii Takuro, Kimura Mika, Kamei Yasutomi, Ogawa Yoshihiro, Hata Kenichiro, Hatada Izuho

Abstract excerpt

Previously, we found that C57BL/6J (B6) mice are more prone to develop obesity than PWK mice. In addition, we analyzed reciprocal crosses between these mice and found that (PWK × B6) F1 mice, which have B6 fathers, are more likely to develop dietary obesity than (B6 × PWK) F1 mice, which have B6 mothers. These results suggested that diet-induced obesity is paternally transmitted. In this study, we performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26868178
DOI: 10.1038/srep21693
PMCID: PMC4751506

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