Article
Searching for genomic region of high-fat diet-induced type 2 diabetes in mouse chromosome 2 by analysis of congenic strains.
PloS one - 1 Jan 2014
Kobayashi Misato, Ohno Tamio, Ihara Kunio, Murai Atsushi, Kumazawa Mayumi, Hoshino Hiromi, Iwanaga Koichiro, Iwai Hiroshi, Hamana Yoshiki, Ito Mikako, Ohno Kinji, Horio Fumihiko
Abstract excerpt
SMXA-5 mice are a high-fat diet-induced type 2 diabetes animal model established from non-diabetic SM/J and A/J mice. By using F2 intercross mice between SMXA-5 and SM/J mice under feeding with a high-fat diet, we previously mapped a major diabetogenic QTL (T2dm2sa) on chromosome 2. We then produced the congenic strain (SM.A-T2dm2sa (R0), 20.8-163.0 Mb) and demonstrated that the A/J allele of T2dm2sa impaired...
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