Article

PARIS/ZNF746 DNA-binding domain deficiency promotes adipose tissue hyperplasia and hepatic lipid accumulation

2025-06-17

Abstract excerpt

<title>Abstract</title> <p>Zinc finger protein 746 (ZNF746), also known as PARKIN-interacting substrate (PARIS), is a KRAB-ZFP family transcriptional repressor implicated in Parkinson’s disease and adipogenesis. Its unclear role in systemic metabolism led us to investigate PARIS-mediated metabolic function by generating mice with a knockout of Znf746 exon 7 (P7KO), containing the DNA-binding domain. Under a high-...

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Literature Corpus work: b5031903-d8de-5940-8875-0fd874a1137b
DOI: 10.21203/rs.3.rs-6475517/v1

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