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Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling.

Physiological genomics - 13 May 2009

Farber Charles R, Aten Jason E, Farber Emily A, de Vera Vincent, Gularte Rodrigo, Islas-Trejo Alma, Wen Pengzi, Horvath Steve, Lucero Michael, Lusis Aldons J, Medrano Juan F

Abstract excerpt

HG.CAST-(D9Mit249-D9Mit133) (HG9) congenic mice are homozygous for CAST/EiJ chromosome (Chr) 9 alleles from approximately 9 to 84 Mbp on a C57BL6/J-hg/hg (HG) background. This region contains the carcass fat in high growth mice (Carfhg2) quantitative trait locus (QTL), and while its obesity-promoting effects have been confirmed in HG9 mice, its underlying genetic basis remains elusive. To refine the location of...

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Identifiers

PMID: 19336533
DOI: 10.1152/physiolgenomics.90245.2008
PMCID: PMC2685499

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CAST

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