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Article

ZFP750 affects the cutaneous barrier through regulating lipid metabolism

28 Apr 2023

Abstract excerpt

An essential function of the epidermis is to provide a physical barrier that prevents the loss of water. Essential mediators of this barrier function include ceramides, cholesterol, and very long chain fatty acids, and their alteration causes human pathologies, including psoriasis and atopic dermatitis. A frameshift mutation in the human ZNF750 gene, which encodes a zinc finger transcription factor, has been...

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PMID: 37115925
DOI: 10.1126/sciadv.adg5423

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