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Article

The origins and evolution of genetic disease risk in modern humans.

Annals of the New York Academy of Sciences - 1 Sept 2010

Crespi Bernard J

Abstract excerpt

Patterns and risks of human disease have evolved. In this article, I review evidence regarding the importance of recent adaptive evolution, positive selection, and genomic conflicts in shaping the genetic and phenotypic architectures of polygenic human diseases. Strong recent selection in human populations can create and maintain genetically based disease risk primarily through three processes: increased scope...

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PMID: 20860684
DOI: 10.1111/j.1749-6632.2010.05707.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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