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Article

Sex differences in disease genetics: evidence, evolution, and detection.

Trends in genetics : TIG - 1 Oct 2014

Gilks William P, Abbott Jessica K, Morrow Edward H

Abstract excerpt

Understanding the genetic architecture of disease is an enormous challenge, and should be guided by evolutionary principles. Recent studies in evolutionary genetics show that sexual selection can have a profound influence on the genetic architecture of complex traits. Here, we summarise data from heritability studies and genome-wide association studies (GWASs) showing that common genetic variation influences many...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25239223
DOI: 10.1016/j.tig.2014.08.006

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