Back to search

Article

Systematic review reveals multiple sexually antagonistic polymorphisms affecting human disease and complex traits

2020-12-18

Abstract excerpt

An evolutionary model for sex differences in disease risk posits that alleles conferring higher risk in one sex may be protective in the other. These sexually antagonistic (SA) alleles are predicted to be maintained at frequencies higher than expected under purifying selection against unconditionally deleterious alleles, but there are apparently no examples in humans. Discipline-specific terminology, rather than a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cd2a49f1-ac4d-5f3c-99ce-7a2e3a10e04a
DOI
10.1101/2020.12.16.20248300
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Systematic review reveals multiple sexually antagonistic polymorphisms affecting human disease and complex traitsDOI 10.1101/2020.12.16.20248300
Systematic review reveals multiple sexually antagonistic polymorphisms affecting human disease and complex traits.Semantic proximity
Polygenic signals of sexually antagonistic selection in contemporary human genomesSemantic proximity
Sex differences in disease genetics: evidence, evolution, and detection.Semantic proximity
The evolution of sex differences in disease geneticsSemantic proximity
More evidence for widespread antagonistic pleiotropy in polymorphic disease allelesSemantic proximity
The evolution of sex differences in diseaseSemantic proximity
Polygenic signals of sex differences in selection in humans from the UK Biobank.Semantic proximity
Sex-specific genetic architecture of human disease.Semantic proximity
The origins and evolution of genetic disease risk in modern humans.Semantic proximity
Understanding rare and common diseases in the context of human evolution.Semantic proximity
Evidence for the role of selection for reproductively advantageous alleles in human aging.Semantic proximity
The autosomal genetic control of sexually dimorphic traits in humans is largely the same across the sexes.Semantic proximity
Select a neighboring publication to make it the new centre.