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Article

Systematic review reveals multiple sexually antagonistic polymorphisms affecting human disease and complex traits.

Evolution; international journal of organic evolution - 1 Dec 2021

Harper Jon Alexander, Janicke Tim, Morrow Edward H

Abstract excerpt

An evolutionary model for sex differences in disease risk posits that alleles conferring higher risk in one sex may be protective in the other. These sexually antagonistic (SA) alleles are predicted to be maintained at frequencies higher than expected under purifying selection against unconditionally deleterious alleles, but there are apparently no examples in humans. Discipline-specific terminology, rather than...

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Identifiers

PMID: 34723381
DOI: 10.1111/evo.14394
PMCID: PMC9299215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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