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Article

Evidence for the role of selection for reproductively advantageous alleles in human aging.

Science advances - 8 Dec 2023

Long Erping, Zhang Jianzhi

Abstract excerpt

The antagonistic pleiotropy hypothesis posits that natural selection for pleiotropic mutations that confer earlier or more reproduction but impair the post-reproductive life causes aging. This hypothesis of the evolutionary origin of aging is supported by case studies but lacks unambiguous genomic evidence. Here, we genomically test this hypothesis using the genotypes, reproductive phenotypes, and death registry...

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Identifiers

PMID: 38064565
DOI: 10.1126/sciadv.adh4990
PMCID: PMC10708185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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