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Article

Evolutionary history of human disease genes reveals phenotypic connections and comorbidity among genetic diseases.

Scientific reports - 1 Jan 2012

Park Solip, Yang Jae-Seong, Kim Jinho, Shin Young-Eun, Hwang Jihye, Park Juyong, Jang Sung Key, Kim Sanguk

Abstract excerpt

The extent to which evolutionary changes have impacted the phenotypic relationships among human diseases remains unclear. In this work, we report that phenotypically similar diseases are connected by the evolutionary constraints on human disease genes. Human disease groups can be classified into slowly or rapidly evolving classes, where the diseases in the slowly evolving class are enriched with morphological...

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Identifiers

PMID: 23091697
DOI: 10.1038/srep00757
PMCID: PMC3477654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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