Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease.

doi:10.1161/CIRCGENETICS.109.923508

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Article

Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease.

Circulation. Cardiovascular genetics - 1 Oct 2010

Musunuru Kiran, Post Wendy S, Herzog William, Shen Haiqing, O'Connell Jeffrey R, McArdle Patrick F, Ryan Kathleen A, Gibson Quince, Cheng Yu-Ching, Clearfield Elizabeth, Johnson Andrew D, Tofler Geoffrey, Yang Qiong, O'Donnell Christopher J, Becker Diane M, Yanek Lisa R, Becker Lewis C, Faraday Nauder, Bielak Lawrence F, Peyser Patricia A, Shuldiner Alan R, Mitchell Braxton D

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified a locus on chromosome 9p21.3 to be strongly associated with myocardial infarction/coronary artery disease and ischemic stroke. To gain insights into the mechanisms underlying these associations, we hypothesized that single nucleotide polymorphisms (SNPs) in this region would be associated with platelet reactivity across multiple populations. METHODS AND...

Topics

Adult
Blood Platelets
Chromosomes, Human, Pair 9
Ethnicity
Female
Genetic Predisposition to Disease
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Myocardial Infarction

Platelet Aggregation

Polymorphism, Single Nucleotide

Vascular Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 20858905
DOI: 10.1161/CIRCGENETICS.109.923508
PMCID: PMC3031788

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20858905-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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