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Article

Replication and hematological characterization of human platelet reactivity genetic associations in men from the Caerphilly Prospective Study (CaPS).

Journal of thrombosis and thrombolysis - 1 Feb 2016

Eicher John D, Xue Luting, Ben-Shlomo Yoav, Beswick Andrew D, Johnson Andrew D

Abstract excerpt

Platelet reactivity, an important factor in hemostasis and chronic disease, has widespread inter-individual variability with a substantial genetic contribution. Previously, our group performed a genome-wide association study of platelet reactivity identifying single nucleotide polymorphisms (SNPs) associated with ADP- and epinephrine- induced aggregation, including SNPs in MRVI1, PIK3CG, JMJD1C, and PEAR1, among...

Topics

Adenosine Diphosphate
Class Ib Phosphatidylinositol 3-Kinase
Epinephrine
Humans
Jumonji Domain-Containing Histone Demethylases
Male
Membrane Proteins
Middle Aged
Oxidoreductases, N-Demethylating
Phosphoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platelet Aggregation

Polymorphism, Single Nucleotide

Receptors, Cell Surface

Source

Open in PubMed Open full text

Identifiers

PMID: 26519038
DOI: 10.1007/s11239-015-1290-7
PMCID: PMC6504920

Genes

PEAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26519038-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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