Article
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
Nature genetics - 1 Jul 2010
Johnson Andrew D, Yanek Lisa R, Chen Ming-Huei, Faraday Nauder, Larson Martin G, Tofler Geoffrey, Lin Shiow J, Kraja Aldi T, Province Michael A, Yang Qiong, Becker Diane M, O'Donnell Christopher J, Becker Lewis C
Abstract excerpt
Platelet function mediates both beneficial and harmful effects on human health, but few genes are known to contribute to variability in this process. We tested association of 2.5 million SNPs with platelet aggregation responses to three agonists (ADP, epinephrine and collagen) in two cohorts of European ancestry (N<or=2,753 in the Framingham Heart Study, N<or=1,238 in the Genetic Study of Atherosclerosis Risk)....
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