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Article

Hirschsprung-associated enterocolitis develops independently of NOD2 variants.

Journal of pediatric surgery - 1 Sept 2010

Lacher Martin, Fitze Guido, Helmbrecht Johanna, Schroepf Sebastian, Berger Michael, Lohse Peter, Koletzko Sibylle, Ballauff Antje, Grote Veit, Goedeke Jan, von Schweinitz Dietrich, Kappler Roland

Abstract excerpt

UNLABELLED: BACKGROUD/PURPOSE: Hirschsprung-associated enterocolitis (HAEC) represents a cause for significant pre- and postoperative morbidity and mortality in Hirschsprung disease (HD). Although multiple studies on HAEC have been performed and several mechanisms have been presumed, the pathogenesis of this condition remains unclear. As changes in colonic mucosal defense are key factors suggested in both Crohn's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20850627
DOI: 10.1016/j.jpedsurg.2010.02.039

Genes

NOD2
RET

Variants

rs2066844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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