Article
The NOD2 Single Nucleotide Polymorphism rs72796353 (IVS4+10 A>C) Is a Predictor for Perianal Fistulas in Patients with Crohn's Disease in the Absence of Other NOD2 Mutations.
PloS one - 1 Jan 2015
Schnitzler Fabian, Friedrich Matthias, Wolf Christiane, Stallhofer Johannes, Angelberger Marianne, Diegelmann Julia, Olszak Torsten, Tillack Cornelia, Beigel Florian, Göke Burkhard, Glas Jürgen, Lohse Peter, Brand Stephan
Abstract excerpt
BACKGROUND: A previous study suggested an association of the single nucleotide polymorphism (SNP) rs72796353 (IVS4+10 A>C) in the NOD2 gene with susceptibility to Crohn's disease (CD). However, this finding has not been confirmed. Given that NOD2 variants still represent the most important predictors for CD susceptibility and phenotype, we evaluated the association of rs72796353 with inflammatory bowel disease...
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